Department of Medical Affairs & Pharmacovigilance • Clinical Formulary Monograph
D 92/6 Okhla Phase 1, New Delhi, 110020, India • Medical Helpline: +91 11-47532297 • Email: contact@vrmedhealthcare.com
PICROGARD-MAX
Ademetionine (SAMe) Hepato-Cellular Formulation
PICROGARD-MAX
Ademetionine (SAMe) Hepato-Cellular Formulation
S-Adenosyl-L-Methionine (Ademetionine) Tablets 400 mg
Product Clinical Overview
PICROGARD-MAX contains S-Adenosyl-L-Methionine (Ademetionine) 400mg, an essential physiological methyl donor and key intermediate in transmethylation, transsulfuration, and aminopropylation pathways. Formulated as enteric-coated tablets for the clinical management of intrahepatic cholestasis in chronic liver diseases and associated somatic debility.
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Actual PICROGARD-MAX packaging, label panels and blister strip.
Key Ingredients & Pharmacological Profiles
Active chemical constituents, standardized strengths, and physiological roles.
Primary biological methyl group donor and biochemical precursor of glutathione in hepatic tissue.
Approved Clinical Indications
Clinical contexts where this formulation is prescribed under medical supervision.
Pharmacological Mechanism of Action
Ademetionine enhances transmethylation reactions that increase hepatocyte membrane fluidity and Na+/K+-ATPase activity, facilitating physiological bile acid secretion. Through transsulfuration, it yields cysteine for synthesis of glutathione, the primary cellular antioxidant.
Formulation & Delivery Technology
- Principal biological donor of methyl groups for hepatic phospholipid and protein methylation
- Precursor in transsulfuration pathway replenishing intracellular hepatic glutathione
- Enteric polymer coating prevents gastric acid degradation, ensuring intact duodenal absorption
VR Med Healthcare Pvt. Ltd.
Registered Office & Facility:D 92/6 Okhla Phase 1, New Delhi, 110020, India
Quality Certifications:WHO-GMP Compliant & ISO 9001:2015 Certified
Medical Helpline:+91 11-47532297
Corporate Email:contact@vrmedhealthcare.com
Administration & Packaging Details
1 tablet (400mg) once or twice daily, taken on an empty stomach 1 hour before meals, as directed by a Gastroenterologist / Physician.
10 x 1 x 10 Tablets (Alu-Alu Strip)
Store below 25°C in a dry place. Protect from heat, light, and moisture.
This formulation monograph is published strictly for the professional scientific reference and educational use of Registered Medical Practitioners, Hospitals, and Clinical Laboratories. The technical and pharmacological details presented herein do not constitute medical advice, diagnostic opinion, or therapeutic claims. These products must be prescribed, dispensed, and administered strictly in accordance with local drug regulations and under the supervision of a licensed physician. VR Med Healthcare Pvt. Ltd. does not promote self-medication, off-label usage, or unsolicited consumer health claims.
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Quality Healthcare & Integrity.
VR Med Healthcare has been a trusted benchmark in the Indian pharmaceutical sector since 2010. Headquartered in Okhla Phase 1, New Delhi, our dedicated team of over 100 professionals collaborates with leading physicians and distributors across India to make premium medicines accessible and reliable.
“Our goal is to deliver quality of care in a courteous, respectful, and compassionate manner. We hope you will allow us to care for you and strive to be the first and best choice for healthcare professionals and families.”
Kamal Choudhary
Managing Director, VR Med Healthcare
Established
Approved Formulations
Healthcare Specialists
Manufacturing Standard